Fig. 6. Functionality of rhodamine-123 transport by accumulation test with or without specific inhibitors of BCRP (KO 143) and P-gp (verapamil), after exposure of cells to 6 h of SH or IH. Results are represented as mean value ± SEM (n=10, N=2), *p≤0.05 between rhodamine and rhodamine + KO 143, ***p≤0.001 between rhodamine before inhibition versus rhodamine with inhibitors. SH: sustained hypoxia, IH: intermittent hypoxia, control: normal atmospheric gas pressure, BCRP: breast cancer related protein, P-gp: P-glycoprotein.